WET GRANULATION METHOD
In the wet granulation process, for get a good viscosity of mixture, usually we use the wetting agent or the binding agent to premix with powder before work with a wet granulation machine. If the material itself has a certain viscosity, but in the case of dry powder, there is no way to play its viscosity, generally, joining some wetting agents like distilled water or ethanol for pretreatment. But for some raw materials which themselves don’t have any stickness or only a little, we suggest to add some binding agents to blend with them for get the desired viscosity such as starch slurry, sodium carboxymethyl cellulose (CMC-Na), hydroxypropyl cellulose (Hpc), methyl cellulose (MC), ethyl cellulose (EC), hydroxypropyl methyl cellulose (HpMC) or other binders such as gelatin solution, sucrose solution, aqueous solution or alcohol solution of polyvinylpyrrolidone.
Anyway, the pharmaceutical granulation equipments are very important for using on tablet manufacturing process. A high quality tablet not made by the tablet press, it is mainly made by powder granulator machine.